Didn't know about this one. Updated.

 Fragile X Syndrome

Large ears and forehead.

A little more research, it is the female chromosome that is the Fragile X.  Because the Y is male.  No per the following the bad X could also come from the Male,?

All hypothetical on my part.  Probably a lot more in depth research on it.

"Is The X male or female?

In most cases, the female is XX and the male is XY. Every individual must have at least one X chromosome. Since the female is XX, each of her eggs has a single X chromosome. The male, being XY, can generate two types of sperm: half bear the X chromosome, half the Y.

https://www.ncbi.nlm.nih.gov › NB...

Chromosomal Sex Determination in Mammals - 

*****'

So let me try and think this one through.

If the offspring with fragile x is male that x chromosome had to have come from the woman!

If the offspring with fragile x is female that x chromosome that is fragile could have come from either the female or the male?  But if the mother didn't first have fragile x it likely came from the male?  If the male had fragile X it came from him? 

Does the female egg have base traits per the x chromosome?  Whereby differentiation is upon the male?  Don't believe that to be true.